Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), a deubiquitylating enzyme of the ubiquitin-specific processing protease family, specifically deubiquitylates both p53 and MDM2, hence playing an important yet enigmatic role in the p53-MDM2 pathway.Here we Lycopene demonstrate that both p53 and MDM2 specifically recogni
Leptospirosis is a human and veterinary illness caused by spirochete bacteria in meaure the genus Leptospira.In symptomatic infection the clinical presentation ranges from non-specific febrile illness to fulminant organ system failure with a high case fatality rate.Leptospires are excreted in the urine of infected mammals with rodents being the mai
Feature-based (FB) algorithms for automatic modulation recognition of radar signals have received much attention since they are usually simple to realize.However, existing FB approaches usually focus on several specific modulations and fail when applied to various modulations.To overcome this issue, we propose a simple and effective FB algorithm ba
Resources are a core currency of species interactions and ecology in general (e.g., think of food webs or competition).Within parasite-infected hosts, resources are divided among the competing demands of host immunity and growth as well as parasite reproduction and growth.Effects of resources on immune responses are increasingly understood at the c